Programme

Friday, 6 June

12:00	Registration
13:00	Lunch
14:00-14:15	Welcome addresses Giorgio Merlo & Caterina Missero
	Session 1: Molecular mechanisms of development and differentiation
14:15-15:00	Plenary Lecture Davide Gabellini (Milan) Molecular pathogenesis of FSHD muscular dystrophy
15:00-17:00	Brief Talks Chairs: D. Gabellini, A. Baldini Maria Armentano (Turin) Rac1 Hyper-activation, by knocking-out GTPase-activating-protein ArhGAP15, disrupts proper architecture and functions of cortical and hippocampal circuits Luisa Cirillo (Naples) Impaired epidermal differentiation leads to severe skin erosions and a systemic autoimmune disease in AEC syndrome Gemma Flore (Naples) Mesodermal expression of Tbx1 is required for cortical development in mice Filomena Gabriella Fulcoli (Naples) Rebalancing gene haploinsufficiency in vivo by targeting chromatin Sara Zribi (Rome) An imbalanced deoxyribonucleoside triphosphate pool hinders DNA replication in reactivated postmitotic cells Sharon Muggeo (Milan) Generation of genetically-corrected induced pluripotent stem cells from osteopetrotic mice and differentiation to the hematopoietic lineage as a cell therapy approach
17:00-17:20	Coffee break
	Session 2: Tissue repair and regenerative medicine
17:20-18:40	Brief Talks Chairs: H. Lickert, E. Illingworth Shikhar Aggarwal (Turin) Adult human renal papilla CD133+ stem/progenitor cells repair glycerol-induced kidney injury in mice Monica Dentice (Naples) The intracellular inactivation of thyroid hormone signaling in muscle stem cells and muscle regeneration Daniele Conte (Turin) Wnt5a/JNK pathway is downstream of Dlx5 and can restore normal limb morphogenesis in the mouse model of ectrodactyly Dlx5;Dlx6 double KO Ombretta Guardiola (Naples) Towards pharmacological modulation of Cripto in skeletal muscle regeneratioe
18:45-19:30	Plenary Lecture Heiko Lickert (Neuherberg, Germany) Beta cell development and regeneration
19:45	Dinner
21:00-21:45	Poster Session

Saturday, 7 June

	Session 3: Stem cell biology and cancer
8:45-9:30	Plenary Lecture Gianvito Martino (Milan) The role of neural stem cells in brain homeostasis and repair
9:30-10:45	Brief Talks Chairs: G. Martino, G. Minchiotti, V. Calautti Anna Musto (Naples) Identification of miRNAs mediating the function of BMP4 in pluripotent stem cells Francesco Neri (Turin) PRC2 recruits Dnmt3L and Tet1 to maintain the promoter of bivalent genes in the hypomethylated state in embryonic stem cells Silvia Pellegrini (Milan) In vitro and in vivo characterization of human induced pluripotent stem cells (hiPSC) differentiation into insulin-producing cells Arianna Petrizzo (Naples) Drosophila as a model system for the study of stem cell dysfunction caused by X-linked dyskeratosis congenita
10:45-11:05	Coffee break
11:05-12:05	Brief Talks Chairs: C. Blanpain, M. Crescenzi Maria Prat (Novara) Isolation and characterization of a spontaneously immortalized multipotent mesenchymal cell line derived from mouse subcutaneous adipose tissue Mara Maldotti (Turin) Long intergenic non-coding RNAs involved in cell cycle control Ivan Colaluca (Milan) Structure/function analysis of the Numb/Hdm2/p53 circuitry in the perspective of therapeutic applications in cancer
12:05-12:55	Plenary Lecture Cedric Blanpain (Brussels, Belgium) Mechanisms regulating stemness in epithelial cancers
13:00-13:10	Closing Remarks
13:10	Lunch

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